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Duratia 90 mg contains Dapoxetine, a medication used to treat premature ejaculation (PE) in men. It works by increasing serotonin levels in the brain, which helps delay ejaculation. While Dapoxetine is effective in treating PE, it can interact with certain herbal supplements, potentially leading to unwanted side effects or reducing the drug's effectiveness.
Reasons for Interaction:
Effect on Serotonin Levels:
Dapoxetine works by increasing serotonin activity in the brain. Certain herbal supplements, like St. John's Wort, are known to affect serotonin levels as well. St. John's Wort, in particular, can increase serotonin and may enhance the effects of Dapoxetine, leading to a risk of serotonin syndrome, a potentially dangerous condition characterized by symptoms like confusion, rapid heart rate, high blood pressure, and seizures.
Impact on Liver Enzymes:
Dapoxetine is metabolized by cytochrome P450 enzymes in the liver, particularly CYP2D6. Some herbal supplements, such as milk thistle and ginseng, may affect liver enzyme activity, either increasing or decreasing the breakdown of the drug. This can lead to higher levels of Dapoxetine in the bloodstream (increasing side effects) or lower levels (reducing its effectiveness).
Blood Pressure Effects:
Some herbal supplements, such as ginseng or hawthorn, can affect blood pressure. Since Dapoxetine can also influence blood pressure, combining it with these herbs could lead to low blood pressure, dizziness, or fainting.
The interaction between Duratia 90 mg and certain herbal supplements mainly arises from their impact on serotonin levels, liver enzymes, or blood pressure. It is important to consult a healthcare provider before combining Dapoxetine with herbal supplements to avoid potential adverse effects or interactions.
Reasons for Interaction:
Effect on Serotonin Levels:
Dapoxetine works by increasing serotonin activity in the brain. Certain herbal supplements, like St. John's Wort, are known to affect serotonin levels as well. St. John's Wort, in particular, can increase serotonin and may enhance the effects of Dapoxetine, leading to a risk of serotonin syndrome, a potentially dangerous condition characterized by symptoms like confusion, rapid heart rate, high blood pressure, and seizures.
Impact on Liver Enzymes:
Dapoxetine is metabolized by cytochrome P450 enzymes in the liver, particularly CYP2D6. Some herbal supplements, such as milk thistle and ginseng, may affect liver enzyme activity, either increasing or decreasing the breakdown of the drug. This can lead to higher levels of Dapoxetine in the bloodstream (increasing side effects) or lower levels (reducing its effectiveness).
Blood Pressure Effects:
Some herbal supplements, such as ginseng or hawthorn, can affect blood pressure. Since Dapoxetine can also influence blood pressure, combining it with these herbs could lead to low blood pressure, dizziness, or fainting.
The interaction between Duratia 90 mg and certain herbal supplements mainly arises from their impact on serotonin levels, liver enzymes, or blood pressure. It is important to consult a healthcare provider before combining Dapoxetine with herbal supplements to avoid potential adverse effects or interactions.