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Harvoni is the combination of Ledipasvir 90mg + Sofosbuvir 400mg. Ledipasvir + Sofosbuvir is a fixed-dose combination direct-acting antiviral drug containing ledipasvir and sofosbuvir for oral administration. Ledipasvir is an inhibitor of the NS5A protein, and sofosbuvir is an inhibitor of the NS5B protein of hepatitis C virus. Ledipasvir is a drug used to treat Hepatitis C genotypes 1 and 4, and is also suitable for patients with Hepatitis C + HIV co-infection. Harvoni cost is global problem.