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Buy Ivermectin cream can take several weeks to show significant improvement in rosacea symptoms. Typically, you may start to notice a reduction in redness, inflammation, and bumps after about 2 to 4 weeks of consistent use. However, it can take longer to achieve full effects, with most clinical studies indicating that the maximum benefit may be seen after about 12 weeks of use. Apply the cream as directed by your healthcare provider, usually once a day. Consistency is key to seeing results.